Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.61 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | MST1R | Q04912 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2092144 | 0.90 | LTA4H (0.49) | LTA4HDPP4RAB9ANPC1ATM | |
| SCHEMBL4848749 | 0.80 | LTA4H (0.61) | LTA4HDPP4RAB9ANPC1ATM | |
| SCHEMBL4845248 | 0.80 | LTA4H (0.61) | LTA4HDPP4RAB9ANPC1ATM | |
| SCHEMBL477614 | 0.80 | LTA4H (0.61) | LTA4HDPP4RAB9ANPC1ATM | |
| SCHEMBL4846964 | 0.80 | LTA4H (0.61) | LTA4HDPP4RAB9ANPC1ATM | |
| SCHEMBL3780733 | 0.80 | LTA4H (0.61) | LTA4HDPP4RAB9ANPC1ATM | |
| SCHEMBL5023959 | 0.80 | LTA4H (0.66) | LTA4HDPP4RAB9ANPC1LTK | |
| SCHEMBL4467348 | 0.79 | LTA4H (0.56) | LTA4HDPP4RAB9ANPC1ATM | |
| Hydrochloric Acid SCHEMBL2463750 | 0.78 | LTA4H (0.59) | LTA4HDPP4RAB9ANPC1ATM | |
| SCHEMBL995326 | 0.78 | LTA4H (0.55) | LTA4HRAB9ANPC1ATMLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1601674-B1 | Hydroxyalkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-08 | — | — | EP | disclosed |
| US-7081463-B2 | Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-25 | — | — | US | disclosed |