Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.44 |
| ▸ | CASP1 | P29466 | 7/20 | 0.44 |
| ▸ | GAA | P10253 | 6/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027508 | 0.92 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10CASP1GAA | |
| SCHEMBL6027973 | 0.90 | KDM4E (0.54) | KDM4EALDH1A1HSD17B10CASP1GAA | |
| SCHEMBL6030181 | 0.88 | KDM4E (0.51) | KDM4EALDH1A1HSD17B10CASP1GAA | |
| SCHEMBL6028402 | 0.88 | KDM4E (0.56) | KDM4EALDH1A1HSD17B10CASP1GAA | |
| SCHEMBL6028121 | 0.86 | KDM4E (0.54) | KDM4EALDH1A1HSD17B10CASP1GAA | |
| SCHEMBL6027814 | 0.86 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10CASP1GAA | |
| SCHEMBL6027379 | 0.85 | GSK3A (0.50) | KDM4EALDH1A1HSD17B10CASP1GAA | |
| SCHEMBL6029934 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10CASP1GAA | |
| SCHEMBL5823596 | 0.84 | HTR1A (0.51) | KDM4EALDH1A1HSD17B10CASP1GAA | |
| SCHEMBL5815676 | 0.84 | HTR1A (0.50) | KDM4EALDH1A1HSD17B10CASP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663227-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | Synta Pharmaceuticals Corporation (US) | 2006-06-07 | — | — | EP | claimed |
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SYNTA PHARMACEUTICAL CORP. | 2005-09-15 | — | — | US | claimed |
| WO-2005025507-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | SYNTA PHAMACEUTICALS CORP. (US) | 2005-03-24 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SLC5A2, SLC5A1, QDPR | KDM4E 2337/4885ALDH1A1 416/4885HSD17B10 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.