Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28473894 | 0.84 | P2RX7 (0.65) | GAAP2RX7KMT2AL3MBTL1MEN1 | |
| SCHEMBL29542612 | 0.83 | LMNA (0.38) | LMNAPOLBGAAP2RX7PLK1 | |
| SCHEMBL26598800 | 0.81 | LMNA (0.50) | LMNAPOLBGAAP2RX7PLK1 | |
| SCHEMBL10435392 | 0.80 | P2RX7 (0.41) | GAAP2RX7KMT2AL3MBTL1MEN1 | |
| SCHEMBL16676654 | 0.80 | LMNA (0.55) | LMNAPOLBGAAP2RX7PLK1 | |
| SCHEMBL12141968 | 0.80 | NSD2 (0.63) | LMNAPOLBGAAKMT2AL3MBTL1 | |
| SCHEMBL2627821 | 0.79 | KDM4E (0.59) | LMNAGAAKMT2AL3MBTL1MEN1 | |
| SCHEMBL16414490 | 0.79 | ALDH1A1 (0.44) | LMNAGAAP2RX7KMT2AL3MBTL1 | |
| SCHEMBL9963329 | 0.79 | TDP1 (0.54) | LMNAPOLBKMT2AL3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL17746066 | 0.78 | KDM4E (0.57) | LMNAGAAKMT2AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125898-B2 | Nicotinamide derivatives useful as p38 inhibitors. | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-24 | — | — | US | disclosed |