Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13570887 | 0.79 | POLQ (0.45) | NOS3NOS2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL7985481 | 0.73 | POLQ (0.41) | NOS3NOS2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL57464 | 0.72 | POLQ (0.40) | NOS3NOS2L3MBTL1HPGDHSD17B10 | |
| SCHEMBL1344896 | 0.71 | NOS3 (0.52) | NOS3NOS2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL18137034 | 0.69 | ADRB2 (0.39) | NOS3NOS2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL59042 | 0.69 | PPARG (0.40) | NOS3NOS2HPGDKMO | |
| SCHEMBL15903091 | 0.69 | GLA (0.41) | GAAHPGDHSD17B10POLQADRB2 | |
| SCHEMBL29553421 | 0.68 | NOS3 (0.48) | NOS3NOS2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL3216629 | 0.68 | NOS3 (0.53) | NOS3NOS2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL8563867 | 0.68 | NOS3 (0.48) | NOS3NOS2ALDH1A1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143393-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-27 | — | — | US | disclosed |