Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030474 | 0.85 | LMNA (0.38) | CA12CA1CA9GAAIRAK4 | |
| SCHEMBL6028951 | 0.85 | IRAK4 (0.35) | IRAK4 | |
| SCHEMBL6313350 | 0.68 | PTGS1 (0.36) | CA12CA1CA9GAABRD9 | |
| SCHEMBL1131491 | 0.67 | CA12 (0.40) | CA12CA1CA9BRD9LMNA | |
| SCHEMBL8713543 | 0.67 | POLB (0.41) | IRAK4LMNANPSR1ALDH1A1POLB | |
| SCHEMBL6978934 | 0.65 | PSEN1 (0.31) | — | |
| Glycine SCHEMBL27518223 | 0.65 | BRD9 (0.37) | CA12CA1CA9BRD9 | |
| SCHEMBL5368528 | 0.65 | LMNA (0.53) | LMNANPSR1ALDH1A1POLB | |
| SCHEMBL3034969 | 0.64 | VDR (0.35) | CA12CA1CA9GAAHCRTR1 | |
| SCHEMBL13513561 | 0.64 | VDR (0.35) | CA12CA1CA9GAAHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008940-B1 | Dihydrobenzofuran derivatives, process for the preparing thereof and agents | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-03-07 | — | — | US | disclosed |
| EP-1213290-B1 | DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA PHARMACEUTICAL (JP) | 2005-04-20 | — | — | EP | disclosed |
| EP-1213290-A1 | DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-12 | — | — | EP | disclosed |