Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 3/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.32 |
| ▸ | ILK | Q13418 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030634 | 0.85 | CA12 (0.33) | IRAK4 | |
| SCHEMBL8713543 | 0.72 | POLB (0.41) | IRAK4TP53MEN1KMT2A | |
| SCHEMBL6030474 | 0.67 | LMNA (0.38) | IRAK4KMT2A | |
| SCHEMBL22695127 | 0.67 | PARP1 (0.35) | — | |
| SCHEMBL22688797 | 0.67 | PTGDR2 (0.31) | — | |
| SCHEMBL22688926 | 0.67 | FFAR4 (0.36) | — | |
| SCHEMBL22688786 | 0.66 | AKT1 (0.32) | AKT1 | |
| SCHEMBL660010 | 0.65 | — | — | |
| SCHEMBL3597744 | 0.65 | GPR35 (0.35) | GPR35TSHR | |
| SCHEMBL17224775 | 0.62 | ALOX5 (0.38) | ALOX5AKT1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008940-B1 | Dihydrobenzofuran derivatives, process for the preparing thereof and agents | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-03-07 | — | — | US | disclosed |
| EP-1213290-B1 | DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | TAKEDA PHARMACEUTICAL (JP) | 2005-04-20 | — | — | EP | disclosed |
| EP-1213290-A1 | DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS | Takeda Chemical Industries, Ltd. (JP) | 2002-06-12 | — | — | EP | disclosed |