Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.62 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | ACACA | Q13085 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230242 | 0.88 | MAPT (0.56) | MAP4K4NR4A1NR4A2NR4A3MRGPRX4 | |
| SCHEMBL1221922 | 0.88 | MAPT (0.63) | NR4A1NR4A2NR4A3SRD5A2PLA2G4B | |
| SCHEMBL6030328 | 0.86 | GABRA5 (0.53) | MAP4K4HDAC1CXCR2MAPTMEN1 | |
| SCHEMBL3759614 | 0.83 | NR4A2 (0.63) | NR4A1NR4A2NR4A3SRD5A2PLA2G4B | |
| Nitrous Acid SCHEMBL27888273 | 0.82 | MAPT (0.56) | MAP4K4NR4A1NR4A2NR4A3SRD5A2 | |
| SCHEMBL25214957 | 0.81 | NR4A1 (0.52) | MAP4K4NR4A1NR4A2NR4A3SRD5A2 | |
| SCHEMBL31108999 | 0.81 | NR4A1 (0.52) | MAP4K4NR4A1NR4A2NR4A3SRD5A2 | |
| SCHEMBL29788015 | 0.80 | MAPT (0.76) | SRD5A2PLA2G4BRXRARXRBMAPT | |
| SCHEMBL2039201 | 0.80 | MAPT (0.76) | SRD5A2PLA2G4BRXRARXRBMAPT | |
| SCHEMBL7094039 | 0.80 | NR4A2 (0.72) | MAP4K4NR4A1NR4A2NR4A3SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060247260-A1 | Bis (hetero) aryl carboxamide derivatives for use as PG12 antagonists | BAYER HEALTHCARE AG (DE) | 2006-11-02 | — | — | US | disclosed |
| EP-1594846-A1 | BIS(HETERO)ARYL CARBOXAMIDE DERIVATIVES FOR USE AS PGI2 ANTAGONISTS | Bayer HealthCare AG (DE) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004069805-A1 | BIS(HETERO)ARYL CARBOXAMIDE DERIVATIVES FOR USE AS PGI2 ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247260-A1 | Bis (hetero) aryl carboxamide derivatives for use as PG12 antagonists | HRH2, BPHL, HRH1 | MAP4K4 2472/4885NR4A1 2600/4885NR4A2 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.