Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.63 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.63 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.63 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.58 |
| ▸ | ACACB | O00763 | 2/20 | 0.58 |
| ▸ | ACACA | Q13085 | 1/20 | 0.58 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.56 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1221922 | 0.85 | MAPT (0.63) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL1221359 | 0.84 | NR4A2 (0.90) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL6339254 | 0.83 | NR4A2 (0.68) | NR4A2NR4A1NR4A3SRD5A2ACACB | |
| SCHEMBL6030735 | 0.83 | MAP4K4 (0.62) | NR4A2NR4A1NR4A3SRD5A2ACACB | |
| SCHEMBL13047644 | 0.81 | ACACB (0.56) | ACACBACACAP4HTMMEN1KMT2A | |
| SCHEMBL1547599 | 0.81 | ACACB (0.53) | ACACBACACAP4HTMMRGPRX4MAOB | |
| Nitrous Acid SCHEMBL27888273 | 0.80 | MAPT (0.56) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL6830467 | 0.78 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL228477 | 0.78 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B | |
| SCHEMBL4059143 | 0.78 | NR4A2 (1.00) | NR4A2NR4A1NR4A3SRD5A2PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136940-A1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| US-20100303758-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2010-12-02 | — | — | US | disclosed |
| US-20100303758-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2010-12-02 | — | — | US | disclosed |
| US-20100303758-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100303758-A1 | Novel Glucocorticoid Receptor Agonists | NR3C1, NR3C2, MC2R | NR4A2 129/4885NR4A1 114/4885NR4A3 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.