Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1128905 | 0.87 | GAA (0.50) | MAPTGAAHSD17B10NPBWR1KCNH2 | |
| SCHEMBL666767 | 0.86 | NPBWR1 (0.43) | NPBWR1KIF11KCNH2METAP2KDM4E | |
| SCHEMBL5015652 | 0.86 | SCN10A (0.45) | KIF11HDAC6KCNH2SCN10AMETAP2 | |
| SCHEMBL9303902 | 0.80 | SHBG (0.39) | MAPTGAANPC1RAB9AAR | |
| SCHEMBL1747974 | 0.73 | KDM4E (0.42) | MAPTHSD17B10NPC1RAB9AMETAP2 | |
| SCHEMBL3490546 | 0.73 | KMT2A (0.44) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL1311258 | 0.72 | NPBWR1 (0.58) | NPBWR1KCNH2SCN10A | |
| SCHEMBL2418844 | 0.72 | SCN10A (0.61) | KCNH2SCN10AMETAP2TRPV1 | |
| SCHEMBL1192946 | 0.72 | F7 (0.47) | MAPTHSD17B10NPC1RAB9AMEN1 | |
| SCHEMBL1193332 | 0.72 | RUNX1 (0.43) | MAPTGAAHSD17B10KIF11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Pharmaceuticals Corporation (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004100881-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-11-25 | — | — | WO | disclosed |