Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031395 | 0.87 | MAPT (0.36) | GAAMAPTHSD17B10SCN10AKCNH2 | |
| SCHEMBL2418844 | 0.86 | SCN10A (0.61) | SCN10AKCNH2TRPV1DYRK1AMETAP2 | |
| SCHEMBL1311258 | 0.86 | NPBWR1 (0.58) | SCN10AKCNH2NPBWR1DGAT1DYRK1A | |
| SCHEMBL9303891 | 0.80 | SCN10A (0.43) | GAAMAPTHSD17B10SCN10AKCNH2 | |
| SCHEMBL827359 | 0.73 | KMT2A (0.58) | GAAMAPTHSD17B10ALDH1A1METAP2 | |
| SCHEMBL1747975 | 0.73 | ALPL (0.56) | ALDH1A1METAP2CBFB | |
| SCHEMBL666767 | 0.72 | NPBWR1 (0.43) | KCNH2NPBWR1DGAT1DYRK1ADYRK1B | |
| SCHEMBL5015652 | 0.72 | SCN10A (0.45) | SCN10AKCNH2TRPV1DYRK1AMETAP2 | |
| SCHEMBL1748354 | 0.72 | ALDH1A1 (0.66) | MAPTHSD17B10ALDH1A1METAP2CBFB | |
| SCHEMBL32674484 | 0.72 | RUNX1 (0.56) | GAAHSD17B10SCN10ATRPV1CBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282762-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | Intermune, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |