Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4495597 | 0.83 | AKR1B1 (0.43) | P2RX7LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4489713 | 0.82 | CCR2 (0.38) | P2RX7LMNASMN1; SMN2 | |
| SCHEMBL5449354 | 0.78 | P2RX7 (0.38) | P2RX7PCSK9 | |
| SCHEMBL4478430 | 0.75 | LMNA (0.43) | P2RX7POLBLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4493255 | 0.74 | MEN1 (0.46) | POLBLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4477879 | 0.74 | MEN1 (0.38) | P2RX7LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4480439 | 0.73 | P2RX7 (0.35) | P2RX7SMN1; SMN2 | |
| SCHEMBL4482091 | 0.72 | FSCN1 (0.34) | P2RX7LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4477812 | 0.72 | LMNA (0.46) | LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4484366 | 0.71 | CCR2 (0.39) | P2RX7LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725556-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005087768-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2005-09-22 | — | — | WO | disclosed |