Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2728632 | 0.92 | ROCK2 (0.51) | ROCK2KDM4EMEN1USP2CYP3A4 | |
| SCHEMBL6031656 | 0.89 | ROCK2 (0.47) | ROCK2KDM4EMEN1USP2CYP3A4 | |
| SCHEMBL6033337 | 0.87 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL6031225 | 0.83 | ROCK2 (0.47) | ROCK2 | |
| SCHEMBL6031918 | 0.82 | ROCK2 (0.53) | ROCK2 | |
| SCHEMBL6032453 | 0.81 | ROCK2 (0.47) | ROCK2 | |
| SCHEMBL10065676 | 0.81 | ROCK2 (0.49) | ROCK2KDM4EMEN1USP2CYP3A4 | |
| SCHEMBL2728687 | 0.81 | ROCK2 (0.66) | ROCK2 | |
| SCHEMBL2725363 | 0.80 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL6032831 | 0.80 | ROCK2 (0.51) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054367-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-26 | — | — | WO | disclosed |