Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 5/20 | 0.60 |
| ▸ | DRD4 | P21917 | 5/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | DRD5 | P21918 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806255 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KDM4EMAPTGAAHTT | |
| Bromide SCHEMBL6030909 | 0.82 | ALDH1A1 (0.73) | ALDH1A1KDM4EMAPTGAAHTT | |
| SCHEMBL5541685 | 0.82 | KDM4E (0.78) | ALDH1A1KDM4EMAPTGAAHTT | |
| SCHEMBL5541696 | 0.82 | KDM4E (0.78) | ALDH1A1KDM4EMAPTGAAHTT | |
| SCHEMBL6031004 | 0.82 | ALDH1A1 (0.78) | ALDH1A1KDM4EMAPTGAAHTT | |
| SCHEMBL11360607 | 0.82 | SIGMAR1 (0.85) | ALDH1A1KDM4EMAPTGAAHTT | |
| SCHEMBL6031039 | 0.81 | ALDH1A1 (0.71) | ALDH1A1KDM4EMAPTGAAHTT | |
| SCHEMBL7521522 | 0.81 | ALDH1A1 (0.63) | ALDH1A1KDM4EMAPTGAAHTT | |
| SCHEMBL6411597 | 0.79 | ALDH1A1 (1.00) | ALDH1A1KDM4EMAPTGAAHTT | |
| SCHEMBL6031654 | 0.78 | MAPT (0.65) | ALDH1A1KDM4EMAPTGAADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101887-B2 | 1-phenyl-4-benzylpiperazines dopamine receptor subtype specific ligands | NEUROGEN CORPORATION (US) | 2006-09-05 | — | — | US | disclosed |
| US-20050239799-A1 | 1-phenyl-4-benzylpiperazines dopamine receptor subtype | NEUROGEN CORPORATION (US) | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239799-A1 | 1-phenyl-4-benzylpiperazines dopamine receptor subtype | DRD2, DRD4, HTR2C | ALDH1A1 567/4885KDM4E 3595/4885MAPT 1859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.