Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL2569555 | 0.89 | FFAR3 (0.50) | ALDH1A1TSHRLMNATDP1THPO | |
| Acetone SCHEMBL100424 | 0.88 | — | — | |
| Acetone SCHEMBL6859028 | 0.88 | LMNA (0.60) | ALDH1A1TSHRLMNATDP1THPO | |
| Acetone SCHEMBL1831044 | 0.88 | LMNA (0.60) | ALDH1A1TSHRLMNATDP1THPO | |
| Acetone SCHEMBL1244296 | 0.88 | LMNA (0.60) | ALDH1A1TSHRLMNATDP1THPO | |
| Acetone SCHEMBL292856 | 0.88 | LMNA (0.60) | ALDH1A1TSHRLMNATDP1THPO | |
| Acetone SCHEMBL6859109 | 0.88 | LMNA (0.60) | ALDH1A1TSHRLMNATDP1THPO | |
| Acetone SCHEMBL9217023 | 0.88 | LMNA (0.60) | ALDH1A1TSHRLMNATDP1THPO | |
| Acetone SCHEMBL6859386 | 0.88 | LMNA (0.60) | ALDH1A1TSHRLMNATDP1THPO | |
| Acetone SCHEMBL4095931 | 0.88 | LMNA (0.60) | ALDH1A1TSHRLMNATDP1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108586363-B | Separation and purification method of L-silk-L-tyrosyl cyclodipeptide and D-silk-L-tyrosyl cyclodipeptide | 苏州卫生职业技术学院 | 2021-07-02 | — | — | CN | claimed |
| CN-108586363-A | A kind of process for separation and purification of L--L- junket Cyclic dipeptides and D--L- junket Cyclic dipeptides | 苏州卫生职业技术学院 | 2018-09-28 | — | — | CN | claimed |
| CN-108586363-B | Separation and purification method of L-silk-L-tyrosyl cyclodipeptide and D-silk-L-tyrosyl cyclodipeptide | 苏州卫生职业技术学院 | 2021-07-02 | — | — | CN | disclosed |
| CN-107513089-B | Novel cytidine derivative dimer and application thereof | 常州方圆制药有限公司 | 2021-04-02 | — | — | CN | disclosed |
| EP-3369740-B1 | NEW CYTIDINE DERIVATIVE DIMERS AND APPLICATIONS THEREOF | Changzhou fangyuan pharmaceutical co ltd (CN) | 2020-11-25 | — | — | EP | disclosed |
| CN-106146583-B | Novel cytidine derivative and use thereof | 常州方圆制药有限公司 | 2019-11-08 | — | — | CN | disclosed |
| US-20190151452-A1 | Polymers Including Active Agents | MICROVENTION, INC. | 2019-05-23 | — | — | US | disclosed |
| US-10226533-B2 | Polymer filaments including pharmaceutical agents and delivering same | MICROVENTION, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| CN-106146584-B | Novel cytidine derivative dimer and use thereof | 常州方圆制药有限公司 | 2019-03-01 | — | — | CN | disclosed |
| EP-3137124-B1 | POLYMERS INCLUDING ACTIVE AGENTS | MICROVENTION INC (US) | 2019-01-09 | — | — | EP | disclosed |
| CN-108586363-A | A kind of process for separation and purification of L--L- junket Cyclic dipeptides and D--L- junket Cyclic dipeptides | 苏州卫生职业技术学院 | 2018-09-28 | — | — | CN | disclosed |
| US-6534114-B2 | Uses multi-slot coating apparatus to apply multiple liquid layers to moving substrate; high speed, for photographic film and paper products | EASTMAN KODAK COMPANY | 2003-03-18 | — | — | US | disclosed |
| US-20020160119-A1 | Coating method | EASTMAN KODAK COMPANY | 2002-10-31 | — | — | US | disclosed |
| US-20020160120-A1 | Coating method for modifying adhesion of thin films to substrates | EASTMAN KODAK COMPANY | 2002-10-31 | — | — | US | disclosed |
| US-4880806-A | BACTERICIDES | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0092352-B1 | 9-SUBSTITUTED CARBACYCLINS | THE UPJOHN COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
| US-4487960-A | 9-Substituted carbacyclin analogs | THE UPJOHN COMPANY (US) | 1984-12-11 | — | — | US | disclosed |
| US-4452986-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | THE UPJOHN COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| EP-0092352-A1 | 9-Substituted carbacyclins | THE UPJOHN COMPANY (US) | 1983-10-26 | — | — | EP | disclosed |
| EP-0069521-A2 | Pyridinyl and imidazolyl derivatives of benzofurans and benzothiophenes | THE UPJOHN COMPANY (US) | 1983-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10226533-B2 | Polymer filaments including pharmaceutical agents and delivering same | MFAP1, ACTB, MAPT | ALDH1A1 3852/4885TSHR 3615/4885LMNA 243/4885 |
| US-20190151452-A1 | Polymers Including Active Agents | MFAP1, VCL, ACTB | ALDH1A1 4019/4885TSHR 4588/4885LMNA 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.