Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.52 |
| ▸ | RXRG | P48443 | 6/20 | 0.52 |
| ▸ | RXRB | P28702 | 5/20 | 0.52 |
| ▸ | RARG | P13631 | 8/20 | 0.52 |
| ▸ | RARB | P10826 | 8/20 | 0.51 |
| ▸ | RARA | P10276 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6877496 | 0.89 | RARG (0.48) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL6878020 | 0.89 | RARB (0.48) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL6876794 | 0.85 | RARG (0.39) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL7022686 | 0.85 | RARG (0.49) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL6874287 | 0.85 | RXRA (0.47) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL6874711 | 0.84 | RARG (0.50) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL6876810 | 0.84 | RXRA (0.53) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL6870442 | 0.84 | RXRA (0.46) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL6477640 | 0.83 | RXRA (0.49) | RXRARXRGRXRBRARGRARB | |
| SCHEMBL6477226 | 0.83 | RXRA (0.49) | RXRARXRGRXRBRARGRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143920-B1 | OIL-IN-WATER EMULSION COMPRISING A MICRONISED BIOLOGICALLY ACTIVE AGENT AND AN APPROPRIATE EMULSIFIER SYSTEM | GALDERMA RES & DEV (FR) | 2003-08-27 | — | — | EP | claimed |
| US-20030135053-A1 | For use in human or veterinary conditions, that may be dermatological, rheumatic, respiratory, or cardiovascular and may be used in cosmetics | BERNARDON JEAN-MICHEL | 2003-07-17 | — | — | US | claimed |
| US-20030060491-A1 | Bicyclic aromatic compounds | BERNARDON JEAN-MICHEL (FR) | 2003-03-27 | — | — | US | claimed |
| US-6515021-B1 | Bicyclic aromatic compounds | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2003-02-04 | — | — | US | claimed |
| EP-0832081-B1 | BICYCLIC-AROMATIC COMPOUNDS | GALDERMA RECH DERMATOLOGIQUE (FR) | 2003-01-29 | — | — | EP | claimed |
| US-20020035161-A1 | O/W emulsions comprising micronized biologically active agents | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2002-03-21 | — | — | US | claimed |
| US-6147255-A | TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL COMPLAINTS ASSOCIATED WITH KERATINIZATION DISORDER WHICH HAS EFFECT ON DIFFERENTIATION AND ON PROLIFERATION | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-11-14 | — | — | US | claimed |
| EP-0832081-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1998-04-01 | — | — | EP | claimed |
| WO-1997033881-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1997-09-18 | — | — | WO | claimed |
| US-20060159638-A1 | O/W emulsions comprising micronized biologically active agents | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2006-07-20 | — | — | US | disclosed |
| US-6825360-B1 | Bicyclic aromatic compounds | GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) | 2004-11-30 | — | — | US | disclosed |
| US-20030135053-A1 | For use in human or veterinary conditions, that may be dermatological, rheumatic, respiratory, or cardiovascular and may be used in cosmetics | BERNARDON JEAN-MICHEL | 2003-07-17 | — | — | US | disclosed |
| US-20030060491-A1 | Bicyclic aromatic compounds | BERNARDON JEAN-MICHEL (FR) | 2003-03-27 | — | — | US | disclosed |
| US-6515021-B1 | Bicyclic aromatic compounds | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2003-02-04 | — | — | US | disclosed |
| EP-0832081-B1 | BICYCLIC-AROMATIC COMPOUNDS | GALDERMA RECH DERMATOLOGIQUE (FR) | 2003-01-29 | — | — | EP | disclosed |
| US-20020035161-A1 | O/W emulsions comprising micronized biologically active agents | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2002-03-21 | — | — | US | disclosed |
| US-6147255-A | TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL COMPLAINTS ASSOCIATED WITH KERATINIZATION DISORDER WHICH HAS EFFECT ON DIFFERENTIATION AND ON PROLIFERATION | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-11-14 | — | — | US | disclosed |
| EP-0832081-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1998-04-01 | — | — | EP | disclosed |
| WO-1997033881-A1 | BICYCLIC-AROMATIC COMPOUNDS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1997-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060491-A1 | Bicyclic aromatic compounds | MITF, TYR, PAH | RXRA 196/4885RXRG 211/4885RXRB 238/4885 |
| US-20020035161-A1 | O/W emulsions comprising micronized biologically active agents | NOTUM, SOAT2, SOAT1 | RXRA 115/4885RXRG 85/4885RXRB 183/4885 |
| US-20030135053-A1 | For use in human or veterinary conditions, that may be dermatological, rheumatic, respiratory, or cardiovascular and may be used in cosmetics | MITF, TYR, PAH | RXRA 55/4885RXRG 87/4885RXRB 91/4885 |
| US-20060159638-A1 | O/W emulsions comprising micronized biologically active agents | NOTUM, SOAT2, SOAT1 | RXRA 126/4885RXRG 83/4885RXRB 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.