Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.54 |
| ▸ | HPGD | P15428 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | VDR | P11473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL915809 | 0.81 | ALDH1A1 (0.61) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL914639 | 0.76 | ALDH1A1 (0.64) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL914501 | 0.74 | ALDH1A1 (0.64) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4187104 | 0.73 | MAPT (0.55) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL913374 | 0.70 | ALDH1A1 (1.00) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1129179 | 0.68 | KDM4E (0.65) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7396348 | 0.67 | ALDH1A1 (0.63) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13762461 | 0.67 | KDM4E (0.70) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7387892 | 0.66 | ALDH1A1 (0.70) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL915806 | 0.66 | HSD17B10 (0.67) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631295-A2 | USE OF FUSED HETEROCYCLIC COMPOUNDS AS SCCE INHIBITORS FOR THE TREATMENT OF SKIN CONDITIONS OR CANCER | Arexis AB (SE) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004108139-A2 | USE OF FUSED HETEROCYCLIC COMPOUNDS AS SCCE INHIBITORS FOR THE TREATMENT OF SKIN CONDITIONS OR CANCER | AREXIS AB (SE) | 2004-12-16 | — | — | WO | disclosed |