Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | USP1 | O94782 | 1/20 | 0.41 |
| ▸ | USP19 | O94966 | 1/20 | 0.41 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4395617 | 0.77 | MAPT (0.61) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL6032690 | 0.77 | MAPT (0.61) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL6031759 | 0.75 | MEN1 (0.65) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL6032369 | 0.73 | ALDH1A1 (0.54) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL914214 | 0.71 | MAPT (1.00) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL812662 | 0.64 | NPC1 (0.53) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL913448 | 0.64 | ELANE (0.78) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL12614772 | 0.62 | PSMB8 (0.68) | MAPTALDH1A1NPC1RAB9ANOTUM | |
| SCHEMBL5963788 | 0.61 | RAB9A (0.61) | MAPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL12927374 | 0.61 | ELANE (0.56) | MAPTALDH1A1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026241-A1 | HETEROCYCLIC MODULATORS OF TGR5 | KALYPSYS, INC. (US) | 2009-02-26 | — | — | WO | disclosed |