Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PPM1B | O75688 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6034101 | 1.00 | GAA (0.34) | GAAMGAMSIMGAM2POLB | |
| SCHEMBL25257468 | 0.88 | MGAM (0.38) | GAAMGAMSIMGAM2POLB | |
| SCHEMBL29023518 | 0.87 | MGAM (0.39) | GAAMGAMSIMGAM2POLB | |
| SCHEMBL25404213 | 0.87 | MGAM (0.39) | GAAMGAMSIMGAM2POLB | |
| SCHEMBL25426819 | 0.84 | FFAR2 (0.34) | SMN1; SMN2ALDH1A1ACEFFAR2 | |
| SCHEMBL25196456 | 0.80 | CYP2D6 (0.38) | KMT2ACYP2D6ACEFFAR2 | |
| SCHEMBL25238755 | 0.80 | CYP2D6 (0.38) | KMT2ACYP2D6ACEFFAR2 | |
| SCHEMBL2733359 | 0.78 | ACE (0.35) | ALDH1A1ACEFFAR2 | |
| SCHEMBL3826730 | 0.78 | ACE (0.37) | ALDH1A1ACEFFAR2 | |
| SCHEMBL25213110 | 0.77 | ALDH1A1 (0.45) | GAAKMT2ASMN1; SMN2ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094800-B2 | pyrrolizinones, e.g., (3S,6R,7aS)-6-amino-5-oxo-hexahydro-pyrrolizine-3-carbonitrile trifluoroacetate, used for reducing blood sugar, treating type 2 diabetes, and treating insulin resistance | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-08-22 | — | — | US | disclosed |
| US-20050059724-A1 | Novel cyanopyrrolidides, process for their preparation and their use as medicaments | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059724-A1 | Novel cyanopyrrolidides, process for their preparation and their use as medicaments | CYP11B2, SLC5A2, CYP11B1 | GAA 1386/4885MGAM 174/4885SI 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.