Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.58 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.56 |
| ▸ | WNT3A | P56704 | 3/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27750743 | 0.95 | KDM4E (0.62) | FLT3CDK2CCNA2CCNA1KDM4E | |
| SCHEMBL82761 | 0.95 | KDM4E (0.62) | FLT3CDK2CCNA2CCNA1KDM4E | |
| Hydrochloric Acid SCHEMBL5071439 | 0.93 | KDM4E (0.60) | FLT3CDK2CCNA2CCNA1KDM4E | |
| Hydrochloric Acid SCHEMBL29962256 | 0.93 | KDM4E (0.60) | FLT3CDK2CCNA2CCNA1KDM4E | |
| Hydrochloric Acid SCHEMBL2175299 | 0.93 | KDM4E (0.60) | FLT3CDK2CCNA2CCNA1KDM4E | |
| Hydrochloric Acid SCHEMBL30404733 | 0.93 | KDM4E (0.60) | FLT3CDK2CCNA2CCNA1KDM4E | |
| SCHEMBL28139037 | 0.93 | KDM4E (0.60) | FLT3CDK2CCNA2CCNA1KDM4E | |
| Trifluoroacetic Acid SCHEMBL15546473 | 0.89 | FLT3 (0.54) | FLT3CDK2CCNA2CCNA1KDM4E | |
| Formic Acid SCHEMBL5987899 | 0.88 | KDM4E (0.55) | FLT3CDK2CCNA2CCNA1KDM4E | |
| SCHEMBL27899707 | 0.85 | KDM4E (0.60) | FLT3CDK2CCNA2CCNA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622892-A1 | INDAZOLES HAVING ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004101548-A1 | INDAZOLE HAVING ANALGESIC ACTIVITY , | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2004-11-25 | — | — | WO | disclosed |