Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6360975 | 0.83 | L3MBTL1 (0.47) | HPGDPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13753327 | 0.79 | POLB (0.46) | HPGDPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13753378 | 0.76 | POLB (0.46) | POLBSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL6160932 | 0.75 | HPGD (0.43) | HPGDPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1621503 | 0.75 | POLB (0.43) | HPGDPOLBSMN1; SMN2MAPK1MEN1 | |
| SCHEMBL1346566 | 0.73 | ALDH1A1 (0.49) | POLBSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL2210472 | 0.72 | HPGD (0.62) | HPGDSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL31469598 | 0.72 | KDM4E (0.68) | HPGDPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL18193848 | 0.71 | NPC1 (0.67) | HPGDSMN1; SMN2NPC1RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL9825967 | 0.71 | KDM4E (0.48) | HPGDPOLBNPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6982279-B2 | Arylated furan- and thiophenecarboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them | AVENTIS PHARM DEUTSCHLAND GMBH (DE) | 2006-01-03 | — | — | US | disclosed |
| US-20040068120-A1 | Arylated furan- and thiophenecarboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068120-A1 | Arylated furan- and thiophenecarboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them | RYR2, CYP4B1, CYP2E1 | HPGD 1703/4885POLB 3566/4885SMN1; SMN2 4620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.