Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6289940 | 0.64 | ALDH1A1 (0.34) | TSHRALDH1A1SMN1; SMN2MAPK1MAPT | |
| SCHEMBL6034342 | 0.62 | TSHR (0.42) | TSHRALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL15124256 | 0.60 | CA1 (0.63) | ALDH1A1SMN1; SMN2MAPTHPGDGAA | |
| SCHEMBL12283671 | 0.58 | ALDH1A1 (0.56) | TSHRALDH1A1SMN1; SMN2MAPK1POLB | |
| SCHEMBL9494419 | 0.58 | TSHR (0.75) | TSHRALDH1A1SMN1; SMN2MAPK1HPGD | |
| SCHEMBL19204661 | 0.57 | CA12 (0.58) | TSHRALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL28668738 | 0.57 | HDAC4 (0.59) | TSHRALDH1A1POLBMAPTGAA | |
| SCHEMBL862728 | 0.56 | ADORA3 (0.46) | ALDH1A1SMN1; SMN2MAPTHPGDHSD17B10 | |
| SCHEMBL11438318 | 0.56 | TSHR (0.38) | TSHRALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL9626894 | 0.55 | TSHR (0.48) | TSHRALDH1A1SMN1; SMN2MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735320-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005097806-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2005-10-20 | — | — | WO | disclosed |