Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9835855 | 0.67 | ALDH1A1 (0.39) | TSHRPOLBHSD17B10KDM4ECYP2C9 | |
| SCHEMBL6034341 | 0.62 | TSHR (0.35) | TSHRPOLBHSD17B10CYP2C9LMNA | |
| SCHEMBL9057095 | 0.60 | TSHR (0.38) | TSHRPOLBHSD17B10KDM4ECYP2C9 | |
| SCHEMBL15124256 | 0.59 | CA1 (0.63) | LMNAMAPTALDH1A1TDP1RAB9A | |
| SCHEMBL9831889 | 0.59 | MAPT (0.32) | LMNAMAPT | |
| SCHEMBL8950215 | 0.59 | HSD11B1 (0.44) | TSHRPOLBHSD17B10KDM4ECYP2C9 | |
| SCHEMBL25060076 | 0.59 | MAPT (0.42) | TSHRPOLBHSD17B10KDM4ELMNA | |
| SCHEMBL12426342 | 0.59 | TSHR (0.44) | TSHRPOLBHSD17B10KDM4ELMNA | |
| SCHEMBL9058353 | 0.58 | TSHR (0.40) | TSHRPOLBHSD17B10KDM4ECYP2C9 | |
| SCHEMBL15614500 | 0.58 | KMT2A (0.47) | TSHRPOLBHSD17B10KDM4ECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735320-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005097806-A1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2005-10-20 | — | — | WO | disclosed |