Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | AHCY | P23526 | 6/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.46 |
| ▸ | GAPDH | P04406 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | STAT6 | P42226 | 1/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404867 | 0.91 | NT5E (0.65) | NT5ELMNAHIF1APRMT5WDR77 | |
| SCHEMBL2052895 | 0.87 | PRMT5 (0.55) | PRMT5WDR77ADORA3ADORA2AADORA2B | |
| SCHEMBL29913822 | 0.84 | PRMT5 (0.69) | HIF1APRMT5WDR77ADORA3ADORA2A | |
| SCHEMBL6035099 | 0.83 | LMNA (0.56) | NT5ELMNAHIF1APRMT5WDR77 | |
| SCHEMBL2047953 | 0.81 | ADORA3 (0.66) | NT5ELMNAHIF1AADORA3ADORA2A | |
| SCHEMBL6034138 | 0.78 | ADORA3 (0.63) | NT5ELMNAHIF1AADORA3ADORA2A | |
| SCHEMBL15012908 | 0.77 | PRMT5 (0.66) | HIF1APRMT5WDR77ADORA3ADORA2A | |
| SCHEMBL16554914 | 0.77 | PRMT5 (0.65) | HIF1APRMT5WDR77ADORA3ADORA2A | |
| Fludarabine SCHEMBL6035031 | 0.76 | LMNA (0.67) | NT5ELMNAHIF1AADORA3ADORA2A | |
| SCHEMBL23884966 | 0.76 | ADORA3 (0.74) | NT5ELMNAHIF1AADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444335-A4 | MUTANT PURINE NUCLEOSIDE PHOSPHORYLASE PROTEINS AND CELLULAR DELIVERY THEREOF | UAB RESEARCH FOUNDATION (US) | 2006-03-08 | — | — | EP | disclosed |
| EP-1444335-A2 | MUTANT PURINE NUCLEOSIDE PHOSPHORYLASE PROTEINS AND CELLULAR DELIVERY THEREOF | UAB Research Foundation (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003035012-A2 | MUTANT PURINE NUCLEOSIDE PHOSPHORYLASE PROTEINS AND CELLULAR DELIVERY THEREOF | UAB RESEARCH FOUNDATION (US) | 2003-05-01 | — | — | WO | disclosed |