Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 2/20 | 0.49 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11609447 | 0.84 | FABP4 (0.59) | MEN1KMT2AAPEX1MPOKDM4E | |
| SCHEMBL15423725 | 0.80 | ALOX15 (0.46) | MEN1KMT2ATDP1ALDH1A1MAPT | |
| SCHEMBL31550899 | 0.80 | ALOX15 (0.46) | MEN1KMT2ATDP1ALDH1A1MAPT | |
| SCHEMBL28361711 | 0.79 | APEX1 (0.60) | MEN1KMT2AAPEX1MPOKDM4E | |
| SCHEMBL109573 | 0.79 | KDM4E (0.60) | MEN1KMT2AAPEX1MPOKDM4E | |
| SCHEMBL22720157 | 0.79 | AKR1C3 (0.62) | MEN1KMT2AMPOKDM4EAKR1C3 | |
| SCHEMBL1323012 | 0.78 | APEX1 (0.58) | MEN1KMT2AAPEX1MPOKDM4E | |
| Hydrochloric Acid SCHEMBL15054390 | 0.78 | APEX1 (0.58) | MEN1KMT2AAPEX1MPOKDM4E | |
| Hydrochloric Acid SCHEMBL143713 | 0.78 | APEX1 (0.58) | MEN1KMT2AAPEX1MPOKDM4E | |
| SCHEMBL22720190 | 0.78 | CTSV (0.68) | MEN1KMT2AAKR1C3AKR1C2AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993437-B1 | 2-(4-BROMO OR 4-IODO PHENYLAMINO) BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2006-11-08 | — | — | EP | claimed |
| EP-0993437-B1 | 2-(4-BROMO OR 4-IODO PHENYLAMINO) BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS | WARNER LAMBERT CO (US) | 2006-11-08 | — | — | EP | disclosed |