Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | RBP4 | P02753 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5671635 | 0.88 | GRM5 (0.49) | GRM5RBP4PROKR1 | |
| SCHEMBL3544759 | 0.82 | RBP4 (0.41) | RBP4ALDH1A1 | |
| SCHEMBL3540773 | 0.77 | RBP4 (0.40) | RBP4 | |
| SCHEMBL3546222 | 0.76 | RBP4 (0.40) | RBP4ALDH1A1 | |
| SCHEMBL4786221 | 0.75 | CNR1 (0.56) | GRM5KDM4EHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL28844354 | 0.75 | RBP4 (0.47) | RBP4PROKR1SLC9A1 | |
| SCHEMBL3544775 | 0.74 | HTR1A (0.40) | RBP4KDM4EALDH1A1HPGD | |
| Bicarbonate SCHEMBL17644450 | 0.73 | TSHR (0.49) | GRM5GAATSHRAGTR1DPP4 | |
| Trifluoroacetic Acid SCHEMBL5669615 | 0.73 | DPP4 (0.43) | GRM5DPP4 | |
| SCHEMBL28766839 | 0.73 | MAPT (0.40) | RBP4CHRM4ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648868-B1 | HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS | CELLTECH R&D LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| EP-1648868-A1 | HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS | Celltech R & D Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2004113298-A1 | HYDROXAMATE SULFONAMIDES AS CD23 SHEDDING INHIBITORS | CELLTECH R & D LIMITED (GB) | 2004-12-29 | — | — | WO | disclosed |