Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6035005 | 0.82 | TGM2 (0.65) | TGM2MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL6034166 | 0.80 | TGM2 (0.66) | TGM2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL6034015 | 0.77 | TGM2 (0.70) | TGM2 | |
| SCHEMBL13407759 | 0.77 | ALDH1A1 (0.78) | MAPTGAAKDM4EALDH1A1MEN1 | |
| SCHEMBL6037625 | 0.77 | TGM2 (1.00) | TGM2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6037643 | 0.76 | TGM2 (0.74) | TGM2MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL4153731 | 0.74 | MAPT (0.52) | TGM2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL4134647 | 0.74 | MAPT (0.52) | TGM2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL4147430 | 0.74 | MAPT (0.51) | TGM2MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL4139711 | 0.74 | MAPT (0.51) | TGM2MAPTGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060183759-A1 | Tissue transglutaminase inhibitors | BRIGHAM AND WOMEN'S HOSPITAL, INC., THE | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183759-A1 | Tissue transglutaminase inhibitors | TGM2, HNMT, TPMT | TGM2 1/4885MAPT 40/4885GAA 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.