Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5275858 | 0.84 | SMN1; SMN2 (0.41) | MAPTGAAPOLBALDH1A1HTT | |
| Trifluoroacetic Acid SCHEMBL6038121 | 0.79 | NPC1 (0.49) | MAPTGAAALDH1A1HTTTP53 | |
| Trifluoroacetic Acid SCHEMBL5275853 | 0.64 | HDAC1 (0.60) | MAPTPOLBALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL5288425 | 0.60 | MAPT (0.63) | MAPTPOLBALDH1A1HTTKDM4E | |
| SCHEMBL6038034 | 0.60 | AKR1C3 (0.61) | GAAALDH1A1KDM4E | |
| SCHEMBL6038024 | 0.59 | HDAC1 (0.61) | MAPTPOLBALDH1A1HTTKDM4E | |
| SCHEMBL6037907 | 0.59 | NPC1 (0.47) | KMT2ARAB9ANPC1 | |
| SCHEMBL5275476 | 0.59 | ALDH1A1 (0.63) | MAPTPOLBALDH1A1HTTKDM4E | |
| SCHEMBL7839582 | 0.58 | HTT (0.46) | MAPTPOLBALDH1A1HTTHPGD | |
| SCHEMBL6038042 | 0.58 | HDAC6 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | MAPT 3848/4885THRB 2728/4885GAA 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.