Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25699746 | 0.77 | ESRRG (0.48) | SMN1; SMN2KMT2ALMNAHPGDMAPT | |
| SCHEMBL15206242 | 0.76 | USP2 (0.49) | SMN1; SMN2PKMALDH1A1HPGDUSP2 | |
| SCHEMBL8234983 | 0.75 | CYP3A4 (0.64) | HTTSMN1; SMN2PKMKMT2AALDH1A1 | |
| SCHEMBL5656305 | 0.74 | RAB9A (0.49) | HSD17B10SMN1; SMN2KMT2AALDH1A1HPGD | |
| SCHEMBL19938019 | 0.73 | MLYCD (0.67) | SMN1; SMN2PKMKMT2AALDH1A1LMNA | |
| SCHEMBL5285176 | 0.72 | TDP1 (0.47) | HTTSMN1; SMN2PKMKMT2AALDH1A1 | |
| SCHEMBL9808088 | 0.71 | ALDH1A1 (0.54) | HTTHSD17B10SMN1; SMN2PKMKMT2A | |
| SCHEMBL6038024 | 0.70 | HDAC1 (0.61) | HTTHSD17B10KMT2AALDH1A1LMNA | |
| SCHEMBL874798 | 0.69 | MAPT (0.53) | HSD17B10SMN1; SMN2KMT2AALDH1A1LMNA | |
| SCHEMBL3892024 | 0.69 | ALDH1A1 (0.46) | HSD17B10SMN1; SMN2KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144381-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000032577-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GMBH (DE) | 2000-06-08 | — | — | WO | disclosed |