SCHEMBL6038198

SCHEMBL6038198

Nc1cc(O)nc(-c2ccncc2)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 6/20 0.46
ADORA1 P30542 2/20 0.46
PDGFRB P09619 2/20 0.40
PDGFRA P16234 2/20 0.40
EGFR P00533 1/20 0.40
QDPR P09417 1/20 0.39
MAPT P10636 3/20 0.39
LMNA P02545 2/20 0.39
MAP4K4 O95819 1/20 0.39
CDK8 P49336 1/20 0.39
CLK2 P49760 1/20 0.39
CDK7 P50613 1/20 0.39
CDK9 P50750 1/20 0.39
CDK5 Q00535 1/20 0.39
ACVR1 Q04771 1/20 0.39
ROCK1 Q13464 1/20 0.39
DYRK1A Q13627 1/20 0.39
LRRK2 Q5S007 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
DYRK1B Q9Y463 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28038683 0.87 ADORA2A (0.52) ADORA2AADORA1PDGFRBPDGFRAMAPT
SCHEMBL6543819 0.85 MAPT (0.48) PDGFRBPDGFRAEGFRQDPRMAPT
SCHEMBL5262287 0.84 ADORA2A (0.66) ADORA2AADORA1MAPTLMNAADORA2B
SCHEMBL5022567 0.82 ADORA2A (0.68) ADORA2AADORA1MAPTLMNADYRK1A
SCHEMBL10942195 0.78 ABCG2 (0.47) ADORA2AADORA1MAPTLMNAHRH4
SCHEMBL5672174 0.78 HTT (0.46) ADORA2AADORA1PDGFRBPDGFRAMAPT
SCHEMBL11515085 0.76 ABCG2 (0.48) PDGFRBPDGFRAEGFRQDPRMAPT
SCHEMBL19054160 0.76 ADORA2A (0.82) ADORA2AADORA1MAPTLMNACDC7
SCHEMBL4803909 0.73 KMT2A (0.59) ADORA2AADORA1MAPTLMNACDC7
SCHEMBL11586178 0.72 ALDH1A1 (0.53) ADORA2AADORA1MAPTLMNACYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1953975-A 2, 6 bisheteroaryl-4-aminopyrimidines as adenosine receptor antagonists ALMIRALL PRODESFARMA AG (CH) 2007-04-25 CN disclosed
EP-1697351-A1 2,6-BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS Almirall Prodesfarma AG (CH) 2006-09-06 EP disclosed
WO-2005058883-A1 2, 6 BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS ALMIRALL PRODESFARMA AG (CH) 2005-06-30 WO disclosed
US-RE30024-E ANTIALLERGENS STERLING DRUG INC. (US) 1979-06-05 US disclosed
US-4118571-A ANTIALLERGENS STERLING DRUG INC. (US) 1978-10-03 US disclosed
US-4086233-A ANTIALLERGENS STERLING DRUG INC. (US) 1978-04-25 US disclosed
US-4053475-A ANTI-ALLERGIC AGENTS STERLING DRUG INC. (US) 1977-10-11 US disclosed
US-4032523-A ANTIALLERGENS STERLING DRUG INC. (US) 1977-06-28 US disclosed
US-4018770-A ANTIALLERGENS STERLING DRUG INC. (US) 1977-04-19 US disclosed
US-4008235-A ANTIALLERGIC STERLING DRUG INC. (US) 1977-02-15 US disclosed