Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086277 | 0.85 | HSP90AB1 (0.52) | NAMPTHSP90AB1HDAC8HDAC6HDAC2 | |
| SCHEMBL16068261 | 0.81 | KEAP1 (0.53) | NAMPTHSP90AB1MEN1KMT2A | |
| SCHEMBL5287307 | 0.79 | HDAC8 (0.61) | NAMPTHDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL2189376 | 0.79 | HDAC8 (0.61) | NAMPTHDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL16271201 | 0.79 | HDAC8 (0.61) | NAMPTHDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL4224259 | 0.79 | HDAC8 (0.61) | NAMPTHDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL27794495 | 0.79 | HDAC8 (0.61) | NAMPTHDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL16212709 | 0.78 | NAMPT (0.83) | NAMPTHDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL19851582 | 0.78 | HDAC8 (0.76) | HDAC8HDAC6HDAC2HDAC3HDAC4 | |
| SCHEMBL16212873 | 0.78 | NAMPT (0.83) | NAMPTHDAC8HDAC6HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | METHYLGENE INC. | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264415-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | NAMPT 1262/4885HSP90AB1 2055/4885HDAC8 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.