Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.40 |
| ▸ | PPME1 | Q9Y570 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | APEH | P13798 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29212295 | 0.75 | KMT2A (0.42) | HTR6LMNASMN1; SMN2AKR1C3AKR1C1 | |
| SCHEMBL16916430 | 0.74 | HTR6 (0.55) | HTR6PPME1LMNAMEN1KMT2A | |
| SCHEMBL5350219 | 0.73 | HTR6 (0.64) | HTR6LMNASMN1; SMN2AKR1C3AKR1C1 | |
| SCHEMBL15598377 | 0.73 | CA1 (0.46) | HTR6LMNACA1CA2MEN1 | |
| SCHEMBL6039683 | 0.72 | HTR6 (0.37) | HTR6CNR2 | |
| SCHEMBL24584311 | 0.72 | BRD4 (0.43) | HTR6PPME1LMNASMN1; SMN2CNR2 | |
| SCHEMBL6039702 | 0.72 | HTR6 (0.53) | HTR6PPME1LMNASMN1; SMN2BRD4 | |
| SCHEMBL4785680 | 0.70 | HTR6 (0.62) | HTR6LMNAMEN1KMT2A | |
| SCHEMBL17179377 | 0.69 | KDM4E (0.47) | HTR6CA1CA2 | |
| SCHEMBL1044745 | 0.69 | BRD4 (0.55) | HTR6PPME1BRD4APEH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038001-A1 | AMINOPYRIMIDINE DERIVATIVES AS JNK INHIBITORS | CELLTECH R & D LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |