Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGPL1 | O95470 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4309974 | 0.81 | GSK3B (0.49) | LMNASIGMAR1ALDH1A1 | |
| SCHEMBL6200965 | 0.72 | HTR2C (0.41) | — | |
| SCHEMBL26898948 | 0.70 | ESR1 (0.53) | ESR1ESR2DRD2DRD3KMT2A | |
| SCHEMBL28735559 | 0.69 | CHRNA7 (0.51) | ESR1ESR2MAPTCHRNA7DRD2 | |
| SCHEMBL4326659 | 0.68 | CYP2D6 (0.48) | MAPTLMNASIGMAR1ALDH1A1 | |
| SCHEMBL2962626 | 0.68 | DRD2 (0.47) | ESR1ESR2MAPTCHRNA7DRD2 | |
| SCHEMBL1143326 | 0.66 | ALOX5 (0.41) | ESR1ESR2MAPTCHRNA7DRD2 | |
| SCHEMBL237422 | 0.65 | TRPV1 (0.37) | SGPL1 | |
| SCHEMBL6179912 | 0.65 | TRPV1 (0.37) | SGPL1 | |
| SCHEMBL23275890 | 0.64 | MAPT (0.43) | MAPTCHRNA7DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071180-B2 | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases | BIOVITRUM AB (SE) | 2006-07-04 | — | — | US | disclosed |