Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 18/20 | 0.41 |
| ▸ | HTR2A | P28223 | 17/20 | 0.41 |
| ▸ | HTR2B | P41595 | 17/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177869 | 0.81 | HTR2A (0.44) | HTR2CHTR2AHTR2B | |
| SCHEMBL239258 | 0.81 | HTR2A (0.44) | HTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL5733483 | 0.79 | HTR2A (0.43) | HTR2CHTR2AHTR2B | |
| SCHEMBL6046297 | 0.72 | SGPL1 (0.39) | — | |
| SCHEMBL5631902 | 0.72 | SLC6A2 (0.50) | HTR2CHTR2AHTR2BROCK2ROCK1 | |
| SCHEMBL5632800 | 0.72 | SLC6A2 (0.50) | HTR2CHTR2AHTR2BROCK2ROCK1 | |
| SCHEMBL29221981 | 0.72 | SLC6A2 (0.50) | HTR2CHTR2AHTR2BROCK2 | |
| SCHEMBL5631907 | 0.72 | SLC6A2 (0.50) | HTR2CHTR2AHTR2BROCK2ROCK1 | |
| SCHEMBL20129704 | 0.71 | PLD1 (0.50) | HTR2CHTR2AHTR2BROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL5632185 | 0.71 | SLC6A2 (0.49) | HTR2CHTR2AHTR2BROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178973-B1 | PYRAZINYL-PIPERAZINE- COMPOUNDS, THEIR USE AND PREPARATION | BIOVITRUM AB (SE) | 2005-12-21 | — | — | EP | disclosed |
| US-6465467-B1 | DISEASES RELATED TO THE 5-HT2C RECEPTOR, ESPECIALLY EATING, MEMORY, MOOD, URINARY AND ANXIETY DISORDERS, SCHIZOPHRENIA, PAIN, SEXUAL DYSFUNCTIONS | BIOVITRUM AB (SE) | 2002-10-15 | — | — | US | disclosed |
| EP-1178973-A2 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | Pharmacia AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000076984-A2 | NOVEL COMPOUNDS, THEIR USE AND PREPARATION | BIOVITRUM AB (SE) | 2000-12-21 | — | — | WO | disclosed |