Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6047786 | 0.97 | MTNR1A (0.43) | MTNR1AMTNR1BTACR2TACR1HRH1 | |
| SCHEMBL6047824 | 0.96 | MTNR1A (0.43) | MTNR1AMTNR1BTACR2TACR1HRH1 | |
| SCHEMBL6047867 | 0.88 | MC4R (0.46) | MTNR1AMTNR1BTACR2TACR1HRH1 | |
| SCHEMBL6047820 | 0.88 | MC4R (0.46) | MTNR1AMTNR1BTACR2TACR1HRH1 | |
| SCHEMBL6047784 | 0.81 | MTNR1A (0.40) | MTNR1AMTNR1B | |
| SCHEMBL4730999 | 0.80 | MTNR1A (0.38) | MTNR1AMTNR1B | |
| SCHEMBL6047793 | 0.80 | TSPO (0.41) | MTNR1AMTNR1B | |
| SCHEMBL6047881 | 0.78 | MTNR1A (0.41) | MTNR1AMTNR1B | |
| SCHEMBL6047801 | 0.78 | MTNR1A (0.37) | MTNR1AMTNR1B | |
| SCHEMBL6047816 | 0.77 | MTNR1A (0.37) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060148805-A1 | Opthalmic compositions for treating ocular hypertension | MERCK SHARP & DOHME CORP. | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148805-A1 | Opthalmic compositions for treating ocular hypertension | KCNH2, KCNH3, KCNN1 | MTNR1A 799/4885MTNR1B 531/4885TACR2 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.