Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 12/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780614 | 0.88 | TSPO (0.44) | TSPOACSS2 | |
| SCHEMBL6047812 | 0.87 | TSPO (0.43) | TSPOACSS2 | |
| SCHEMBL6047793 | 0.85 | TSPO (0.41) | TSPOACSS2 | |
| SCHEMBL6047769 | 0.85 | KDM4E (0.43) | TSPOGAAACSS2 | |
| SCHEMBL6047815 | 0.84 | MTNR1A (0.43) | TSPOACSS2 | |
| SCHEMBL6047874 | 0.83 | MC4R (0.45) | TSPOACSS2 | |
| SCHEMBL4696223 | 0.83 | MTNR1A (0.43) | TSPOGAAACSS2 | |
| SCHEMBL4696635 | 0.82 | BRD4 (0.53) | TSPOTP53ACSS2 | |
| SCHEMBL6047822 | 0.82 | MC4R (0.42) | TSPO | |
| SCHEMBL6047805 | 0.81 | MTNR1A (0.41) | TSPOGAAACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060148805-A1 | Opthalmic compositions for treating ocular hypertension | MERCK SHARP & DOHME CORP. | 2006-07-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148805-A1 | Opthalmic compositions for treating ocular hypertension | KCNH2, KCNH3, KCNN1 | TSPO 491/4885TP53 4722/4885RXFP1 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.