Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSPO | P30536 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6047806 | 0.94 | ALDH1A1 (0.44) | ALDH1A1TDP1TSPOMEN1KMT2A | |
| SCHEMBL6047815 | 0.92 | MTNR1A (0.43) | TSPOLMNAPOLB | |
| SCHEMBL6047788 | 0.91 | CNR2 (0.43) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL6047764 | 0.90 | ALDH1A1 (0.45) | ALDH1A1TDP1TSPOMEN1KMT2A | |
| SCHEMBL6047761 | 0.89 | ALDH1A1 (0.43) | ALDH1A1TDP1CNR1CNR2 | |
| SCHEMBL6047805 | 0.88 | MTNR1A (0.41) | ALDH1A1TSPOLMNACNR2NPC1 | |
| SCHEMBL6047784 | 0.87 | MTNR1A (0.40) | TSPOLMNAPOLB | |
| SCHEMBL6047783 | 0.87 | CNR2 (0.46) | ALDH1A1TDP1TSPOMEN1KMT2A | |
| SCHEMBL6047825 | 0.86 | CNR2 (0.47) | ALDH1A1TDP1TSPOMEN1KMT2A | |
| SCHEMBL4696223 | 0.86 | MTNR1A (0.43) | ALDH1A1TSPOLMNACNR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060148805-A1 | Opthalmic compositions for treating ocular hypertension | MERCK SHARP & DOHME CORP. | 2006-07-06 | — | — | US | claimed |
| US-20060148805-A1 | Opthalmic compositions for treating ocular hypertension | MERCK SHARP & DOHME CORP. | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148805-A1 | Opthalmic compositions for treating ocular hypertension | KCNH2, KCNH3, KCNN1 | ALDH1A1 2026/4885TDP1 3412/4885TSPO 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.