Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604400 | 0.71 | HRH4 (0.46) | HRH4 | |
| SCHEMBL8878356 | 0.67 | MTNR1A (0.53) | — | |
| Hydrochloric Acid SCHEMBL32673083 | 0.66 | MTNR1A (0.51) | — | |
| SCHEMBL28261884 | 0.65 | HRH4 (0.44) | HRH4PARP1IKBKBMPO | |
| SCHEMBL28261886 | 0.65 | HRH4 (0.44) | HRH4PARP1IKBKBMPO | |
| SCHEMBL9842899 | 0.65 | HTR1A (0.46) | — | |
| SCHEMBL4001085 | 0.65 | HRH4 (0.39) | HRH4DHFR | |
| SCHEMBL13771839 | 0.64 | LIMK1 (0.60) | HRH4 | |
| SCHEMBL5839494 | 0.64 | HTR2C (0.47) | — | |
| SCHEMBL4985913 | 0.64 | HRH4 (0.39) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120039913-A1 | Selective Histamine H4 Receptor Antagonists for the Treatment of Vestibular Disorders | INSERM (institut National de la Sante de la Recher Medicale) (FR) | 2012-02-16 | — | — | US | disclosed |
| EP-2382013-A1 | SELECTIVE HISTAMINE H4 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VESTIBULAR DISORDERS. | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2011-11-02 | — | — | EP | disclosed |