Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5520519 | 0.85 | FAAH (0.43) | KMT2AMEN1TP53ALDH1A1XDH | |
| SCHEMBL14110447 | 0.82 | KMT2A (0.46) | KMT2AMEN1TP53PARP3LMNA | |
| SCHEMBL5581797 | 0.80 | FAAH (0.46) | KMT2ATP53LMNAALDH1A1XDH | |
| SCHEMBL5581487 | 0.76 | FAAH (0.45) | KMT2ATP53ALDH1A1XDHKDM4E | |
| SCHEMBL5520457 | 0.73 | TP53 (0.40) | KMT2AMEN1TP53LMNAALOX12 | |
| SCHEMBL2701430 | 0.70 | MAPT (0.57) | KMT2AMEN1LMNAALOX12ALDH1A1 | |
| SCHEMBL6048149 | 0.70 | FAAH (0.48) | KMT2ATP53LMNAALDH1A1XDH | |
| SCHEMBL5095572 | 0.69 | MEN1 (0.51) | KMT2AMEN1TP53LMNAALDH1A1 | |
| SCHEMBL5581813 | 0.69 | FAAH (0.50) | KMT2ATP53LMNAALDH1A1XDH | |
| SCHEMBL10829015 | 0.68 | MAOB (0.52) | KMT2AMEN1TP53LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716158-A2 | SILINANE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | Schering Aktiengesellschaft (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005074904-A2 | SILINANE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-08-18 | — | — | WO | disclosed |