Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.48 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | HSF1 | Q00613 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 2/20 | 0.38 |
| ▸ | ATP4B | P51164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5581813 | 0.97 | FAAH (0.50) | FAAHCES1HSF1KMT2AALDH1A1 | |
| SCHEMBL5581487 | 0.93 | FAAH (0.45) | FAAHCES1HSF1KMT2AALDH1A1 | |
| SCHEMBL5581797 | 0.90 | FAAH (0.46) | FAAHCES1HSF1KMT2AALDH1A1 | |
| SCHEMBL14110504 | 0.83 | FAAH (0.51) | FAAHCES1HSF1KMT2AALDH1A1 | |
| SCHEMBL5520519 | 0.83 | FAAH (0.43) | FAAHCES1HSF1KMT2AALDH1A1 | |
| SCHEMBL14110445 | 0.76 | FAAH (0.47) | FAAHCES1HSF1ALDH1A1DAGLA | |
| SCHEMBL14110574 | 0.73 | FAAH (0.47) | FAAHCES1KMT2AALDH1A1MAPT | |
| SCHEMBL7533229 | 0.73 | FAAH (0.41) | FAAHCES1HSF1KMT2AALDH1A1 | |
| SCHEMBL6465050 | 0.72 | FAAH (0.52) | FAAHCES1HSF1KMT2AALDH1A1 | |
| SCHEMBL6465186 | 0.72 | ALDH1A1 (0.44) | FAAHCES1HSF1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716158-A2 | SILINANE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | Schering Aktiengesellschaft (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005074904-A2 | SILINANE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-08-18 | — | — | WO | disclosed |