Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049335 | 0.86 | L3MBTL1 (0.39) | KCNH2TSHRMAPK1TDP1L3MBTL1 | |
| SCHEMBL6049377 | 0.80 | MAPT (0.41) | L3MBTL1 | |
| SCHEMBL6049355 | 0.78 | MAPK1 (0.42) | TSHRMAPK1TDP1L3MBTL1NR1H2 | |
| SCHEMBL6049337 | 0.77 | L3MBTL1 (0.52) | L3MBTL1 | |
| SCHEMBL6049333 | 0.74 | CETP (0.38) | TSHRMAPK1TDP1L3MBTL1 | |
| SCHEMBL11251764 | 0.70 | TAAR1 (0.45) | CYP2D6 | |
| SCHEMBL6647118 | 0.69 | PPARA (0.54) | KCNH2CYP2D6 | |
| SCHEMBL3966817 | 0.68 | TDP1 (0.49) | KCNH2CYP2D6TSHRMAPK1TDP1 | |
| SCHEMBL4160475 | 0.68 | KCNH2 (0.51) | KCNH2CYP2D6 | |
| SCHEMBL28032739 | 0.67 | TAAR1 (0.58) | TSHRMAPK1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539136-A4 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK & CO INC (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1539136-A2 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | Merck & Co., Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004010936-A2 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | disclosed |