Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049335 | 0.86 | L3MBTL1 (0.39) | MAPK1L3MBTL1TSHRTDP1GGPS1 | |
| SCHEMBL12866793 | 0.80 | GGPS1 (0.50) | MAPK1L3MBTL1TSHRTDP1GGPS1 | |
| SCHEMBL10224056 | 0.79 | GGPS1 (0.46) | MAPK1L3MBTL1TSHRGGPS1PLA2G4B | |
| SCHEMBL6049352 | 0.78 | KCNH2 (0.43) | MAPK1L3MBTL1TSHRTDP1NR1H2 | |
| SCHEMBL10224068 | 0.77 | GGPS1 (0.48) | MAPK1TSHRGGPS1KDM4EALDH1A1 | |
| SCHEMBL12775663 | 0.77 | ALDH1A1 (0.48) | MAPK1L3MBTL1TSHRTDP1GGPS1 | |
| SCHEMBL10223981 | 0.77 | GGPS1 (0.42) | MAPK1L3MBTL1TSHRTDP1GGPS1 | |
| SCHEMBL12775724 | 0.75 | TP53 (0.56) | MAPK1TSHRGGPS1KDM4EALDH1A1 | |
| SCHEMBL16841500 | 0.75 | GGPS1 (0.41) | TSHRGGPS1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL278395 | 0.74 | FAAH (0.42) | GGPS1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539136-A4 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK & CO INC (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1539136-A2 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | Merck & Co., Inc. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004010936-A2 | PPAR ALPHA SELECTIVE COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND OTHER LIPID DISORDERS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | disclosed |