Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049586 | 0.78 | MAPK14 (0.45) | MAPK14ALOX5MEN1MAPK1KMT2A | |
| SCHEMBL6924580 | 0.74 | MAPK14 (0.54) | MAPK14ALOX5 | |
| SCHEMBL6812678 | 0.73 | MRGPRX4 (0.42) | MEN1KMT2A | |
| SCHEMBL6817457 | 0.70 | AKR1B1 (0.40) | MEN1MAPK1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1305897 | 0.70 | PPARA (0.49) | MEN1KMT2APOLBCYP1A2CYP3A4 | |
| SCHEMBL9894387 | 0.70 | MAPK14 (0.38) | MAPK14 | |
| SCHEMBL13388165 | 0.69 | IDH2 (0.35) | MAPK14MEN1KMT2A | |
| SCHEMBL6049549 | 0.68 | PARP10 (0.39) | MAPK14MEN1KMT2A | |
| SCHEMBL13388539 | 0.68 | RORB (0.38) | MAPK14MEN1KMT2ACYP2C19 | |
| SCHEMBL4420926 | 0.67 | MAPK14 (0.56) | MAPK14MEN1KMT2ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041982-A4 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-14 | — | — | EP | disclosed |
| EP-1041982-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | Bayer Corporation (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032111-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |