Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6049504 | 0.78 | MAPK14 (0.47) | MAPK14ALOX5MAPK1KMT2AMEN1 | |
| SCHEMBL6924580 | 0.76 | MAPK14 (0.54) | MAPK14ALOX5 | |
| SCHEMBL6613447 | 0.69 | RXRA (0.35) | MAPK14 | |
| SCHEMBL9894387 | 0.69 | MAPK14 (0.38) | MAPK14 | |
| SCHEMBL3631505 | 0.68 | MAPK14 (0.53) | MAPK14 | |
| SCHEMBL7552627 | 0.68 | TSHR (0.36) | MAPK14MAPK1KMT2AMEN1TSHR | |
| SCHEMBL17513254 | 0.68 | TSHR (0.41) | KMT2AMEN1POLBTSHR | |
| SCHEMBL13388539 | 0.68 | RORB (0.38) | MAPK14KMT2AMEN1 | |
| SCHEMBL1305897 | 0.67 | PPARA (0.49) | KMT2AMEN1POLBTSHR | |
| SCHEMBL4420926 | 0.66 | MAPK14 (0.56) | MAPK14KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1041982-A4 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER PHARMACEUTICALS CORP (US) | 2006-06-14 | — | — | EP | disclosed |
| EP-1041982-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | Bayer Corporation (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032111-A1 | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |