Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13388539 | 0.76 | RORB (0.38) | MAPK14MAPTRXRARXRBHPGD | |
| SCHEMBL6049586 | 0.76 | MAPK14 (0.45) | MAPK14ALOX5 | |
| SCHEMBL6049504 | 0.74 | MAPK14 (0.47) | MAPK14ALOX5 | |
| SCHEMBL4478253 | 0.70 | MAPK14 (1.00) | MAPK14MAPTRAF1MAPK13MAPK12 | |
| SCHEMBL13388165 | 0.68 | IDH2 (0.35) | MAPK14MAPTHSD17B10NPC1 | |
| SCHEMBL6824297 | 0.67 | DAO (0.36) | MAPK14MAPTRXRARXRBRXRG | |
| SCHEMBL9894387 | 0.67 | MAPK14 (0.38) | MAPK14RAF1MAPK11 | |
| SCHEMBL4420926 | 0.66 | MAPK14 (0.56) | MAPK14MAPTRAF1HPGDKDM4E | |
| SCHEMBL3631505 | 0.66 | MAPK14 (0.53) | MAPK14MAPTRAF1MAPK13MAPK12 | |
| SCHEMBL7552627 | 0.66 | TSHR (0.36) | MAPK14MAPTHPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043995-A4 | INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS | BAYER AG (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-1043995-A1 | INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS | Bayer Corporation (US) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999032110-A1 | INHIBITION OF p38 KINASE ACTIVITY USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |