Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 17/20 | 0.35 |
| ▸ | CA2 | P00918 | 17/20 | 0.35 |
| ▸ | CA9 | Q16790 | 15/20 | 0.35 |
| ▸ | CA12 | O43570 | 5/20 | 0.34 |
| ▸ | CA7 | P43166 | 5/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.34 |
| ▸ | CA3 | P07451 | 4/20 | 0.34 |
| ▸ | CA4 | P22748 | 4/20 | 0.34 |
| ▸ | CA6 | P23280 | 4/20 | 0.34 |
| ▸ | CA5A | P35218 | 4/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20597785 | 0.86 | USP2 (0.46) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL19458673 | 0.82 | KDM4E (0.37) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL24089563 | 0.81 | TSHR (0.54) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL6656121 | 0.80 | RECQL (0.59) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL27447673 | 0.78 | TSHR (0.60) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL24089535 | 0.78 | KDM4E (0.48) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL6231039 | 0.77 | FNTA (0.34) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| Busulfan SCHEMBL4764696 | 0.76 | TSHR (1.00) | TSHRKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL7753817 | 0.76 | THRB (0.44) | LMNA | |
| Busulfan SCHEMBL4373 | 0.76 | TSHR (1.00) | TSHRKDM4EUSP2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912179-B1 | DEOXYNOJIRIMYCIN DERIVATIVES AND THEIR USES AS GLUCOSYLCERAMIDASE INHIBITORS | MACROZYME DNM B V (NL) | 2006-04-12 | — | — | EP | disclosed |
| US-6177447-B1 | THERAPY FOR GAUCHER'S DISEASE | UNIVERSITEIT VAN AMSTERDAM (NL) | 2001-01-23 | — | — | US | disclosed |
| EP-0912179-A1 | DEOXYNOJIRIMYCIN DERIVATIVES AND THEIR USES AS GLUCOSYLCERAMIDASE INHIBITORS | Universiteit van Amsterdam (NL) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998002161-A1 | DEOXYNOJIRIMYCIN DERIVATIVES AND THEIR USES AS GLUCOSYLCERAMIDASE INHIBITORS | UNIVERSITEIT VAN AMSTERDAM (NL) | 1998-01-22 | — | — | WO | disclosed |