Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15270512 | 0.87 | PARP10 (0.46) | ALOX15GFERADAM17KMT2AATM | |
| SCHEMBL29145870 | 0.86 | KMT2A (0.51) | ALOX15GFERADAM17KMT2AATM | |
| SCHEMBL6051031 | 0.85 | ALOX15 (0.46) | ALOX15GFERADAM17KMT2AATM | |
| SCHEMBL1018588 | 0.81 | KMT2A (0.64) | ALOX15GFERADAM17KMT2AATM | |
| Hydrochloric Acid SCHEMBL9015381 | 0.79 | KMT2A (0.62) | ALOX15GFERADAM17KMT2AATM | |
| SCHEMBL2954084 | 0.78 | DRD1 (0.59) | ALOX15GFERADAM17KMT2AATM | |
| Paraben SCHEMBL6051026 | 0.77 | CA2 (0.57) | ALOX15ALDH1A1TSHRHTTSRD5A2 | |
| SCHEMBL613183 | 0.76 | PDE4D (0.51) | ALOX15GFERADAM17KMT2AMAPT | |
| SCHEMBL2949700 | 0.75 | SMN1; SMN2 (0.40) | KMT2AALDH1A1HTTMEN1MAPT | |
| SCHEMBL16629709 | 0.71 | KMT2A (0.47) | ALOX15GFERADAM17KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9145365-B2 | Process for the preparation of Roflumilast | Mylan Laboratories Ltd. (IN) | 2015-09-29 | — | — | US | claimed |
| US-20140275551-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | Mylan Laboratories Ltd. (IN) | 2014-09-18 | — | — | US | claimed |
| EP-2776395-A2 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | Mylan Laboratories, Limited (IN) | 2014-09-17 | — | — | EP | claimed |
| WO-2013072938-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF ROFLUMILAST | MYLAN LABORATORIES LTD (IN) | 2013-05-23 | — | — | WO | claimed |
| EP-1670742-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | Ranbaxy Laboratories Limited (IN) | 2006-06-21 | — | — | EP | claimed |
| WO-2005026095-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | RANBAXY LABORATORIES LIMITED (IN) | 2005-03-24 | — | — | WO | claimed |
| CN-105646338-A | Preparation method of Roflumilast | 陈红 | 2016-06-08 | — | — | CN | disclosed |
| US-9145365-B2 | Process for the preparation of Roflumilast | Mylan Laboratories Ltd. (IN) | 2015-09-29 | — | — | US | disclosed |
| US-20140275551-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | Mylan Laboratories Ltd. (IN) | 2014-09-18 | — | — | US | disclosed |
| EP-2776395-A2 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | Mylan Laboratories, Limited (IN) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013072938-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF ROFLUMILAST | MYLAN LABORATORIES LTD (IN) | 2013-05-23 | — | — | WO | disclosed |
| EP-1670742-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | Ranbaxy Laboratories Limited (IN) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005026095-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | RANBAXY LABORATORIES LIMITED (IN) | 2005-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275551-A1 | PROCESS FOR THE PREPARATION OF ROFLUMILAST | TFPI, CMA1, F2R | ALOX15 988/4885GFER 1501/4885ADAM17 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.