SCHEMBL1018588

SCHEMBL1018588

O=C(O)c1ccc(OC(F)F)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.64
ALOX15 P16050 1/20 0.63
GFER P55789 1/20 0.63
ADAM17 P78536 1/20 0.63
ATM Q13315 1/20 0.59
MRGPRX4 Q96LA9 1/20 0.55
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
ALDH1A1 P00352 6/20 0.53
TSHR P16473 3/20 0.53
SRD5A2 P31213 2/20 0.53
HSD17B10 Q99714 1/20 0.53
TP53 P04637 1/20 0.52
MEN1 O00255 1/20 0.50
MAPT P10636 1/20 0.50
TEAD4 Q15561 1/20 0.50
HTT P42858 2/20 0.49
PARP15 Q460N3 1/20 0.48
PARP10 Q53GL7 1/20 0.48
KDM4E B2RXH2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9015381 0.98 KMT2A (0.62) KMT2AALOX15GFERADAM17ATM
SCHEMBL29145870 0.88 KMT2A (0.51) KMT2AALOX15GFERADAM17ATM
SCHEMBL4118525 0.86 EPHX2 (0.58) KMT2AALOX15GFERADAM17ATM
SCHEMBL7042503 0.84 ALOX15 (0.66) KMT2AALOX15GFERADAM17ATM
SCHEMBL2791684 0.84 ALOX15 (0.66) KMT2AALOX15GFERADAM17ATM
SCHEMBL19554267 0.84 KDM4E (0.62) KMT2AALOX15GFERADAM17ATM
SCHEMBL24400226 0.83 ALOX15 (0.63) ALOX15GFERADAM17ATMALDH1A1
SCHEMBL28208867 0.83 ALOX15 (0.63) KMT2AALOX15GFERADAM17ATM
SCHEMBL25197353 0.82 XDH (0.67) KMT2AALDH1A1MEN1MAPT
SCHEMBL25204412 0.82 XDH (0.67) KMT2AALDH1A1MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 352 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4127157-B1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS ENCODIA INC (US) 2026-02-11 EP claimed
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN claimed
US-20240011009-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2024-01-11 US claimed
US-20230220589-A1 POLYPEPTIDE TERMINAL BINDERS AND USES THEREOF Encodia, Inc. (US) 2023-07-13 US claimed
EP-4127157-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2023-02-08 EP claimed
WO-2022072560-A1 POLYPEPTIDE TERMINAL BINDERS AND USES THEREOF Encodia, Inc. (US) 2022-04-07 WO claimed
WO-2021194908-A1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2021-09-30 WO claimed
CN-109516949-A A kind of preparation method of roflumilast 安徽省庆云医药股份有限公司 2019-03-26 CN claimed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 US disclosed
US-12577206-B2 Pyrazolone formyl peptide 2 receptor agonists BRISTOL-MYERS SQUIBB COMPANY (US) 2026-03-17 US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 EP disclosed
EP-4127157-B1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS ENCODIA INC (US) 2026-02-11 EP disclosed
US-20260022108-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF TENARX, INC. 2026-01-22 US disclosed
US-20250388604-A1 Compounds and Their Use as PDE4 Activators MIRONID LIMITED (GB) 2025-12-25 US disclosed
EP-0659737-A2 Catecholamine surrogates useful as B3 agonists BRISTOL-MYERS SQUIBB COMPANY (US) 1995-06-28 EP disclosed
US-5389292-A Liquid crystalline media having positive dielctric anisotropy, chemical, heat and radiation resistance, used as electro-optical displaying MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1995-02-14 US disclosed
EP-0381728-B1 DIFLUOROMETHYL COMPOUNDS MERCK PATENT GMBH (DE) 1993-12-08 EP disclosed
EP-0381728-A1 DIFLUOROMETHYL COMPOUNDS. MERCK PATENT GMBH (DE) 1990-08-16 EP disclosed
WO-1990001056-A1 DIFLUOROMETHYL COMPOUNDS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1990-02-08 WO disclosed
US-4009208-A N,N'-HEPTAMETHYLENEBIS(4-METHOXYBENZAMIDE) STERLING DRUG INC. (US) 1977-02-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577206-B2 Pyrazolone formyl peptide 2 receptor agonists FPR2, FPR1, FPR3 KMT2A 4664/4885ALOX15 631/4885GFER 1974/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH KMT2A 3729/4885ALOX15 356/4885GFER 3197/4885
US-20250388604-A1 Compounds and Their Use as PDE4 Activators PDE4A, PDE7A, PDE4B KMT2A 3462/4885ALOX15 3238/4885GFER 3394/4885
US-20260022108-A1 ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF WNT1, WNT3, WNT3A KMT2A 2233/4885ALOX15 4225/4885GFER 3837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.