Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pitolisant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 16/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.61 |
| ▸ | HRH1 | P35367 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.61 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6052840 | 0.95 | HRH3 (0.64) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL6052607 | 0.86 | SIGMAR1 (0.65) | HRH3SIGMAR1 | |
| SCHEMBL491602 | 0.84 | HRH3 (0.68) | HRH3 | |
| SCHEMBL491873 | 0.83 | HRH3 (0.63) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL491900 | 0.83 | HRH3 (0.63) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL491585 | 0.83 | HRH3 (0.63) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL491791 | 0.82 | HRH3 (0.72) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL12741679 | 0.81 | HRH3 (0.61) | HRH3SIGMAR1 | |
| SCHEMBL5484748 | 0.81 | HRH3 (0.61) | HRH3SIGMAR1 | |
| SCHEMBL491586 | 0.81 | HRH3 (0.61) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641461-A1 | COMBINATION PRODUCT COMPRISING AN ANTAGONIST OR INVERSE AGONIST OF HISTAMINE RECEPTOR H<SB>3</SB>AND AN ANTIPSYCHOTIC OR ANTIDEPRESSANT AGENT, AND USE THEREOF FOR THE PREPARATION OF A MEDICAMENT THAT PREVENTS THE ADVERSE EFFECTS OF PSYCHOTROPIC DRUGS | BIOPROJET (FR) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005000315-A1 | COMBINATION PRODUCT COMPRISING AN ANTAGONIST OR INVERSE AGONIST OF HISTAMINE RECEPTOR H3 AND AN ANTIPSYCHOTIC OR ANTIDEPRESSANT AGENT, AND USE THEREOF FOR THE PREPARATION OF A MEDICAMENT THAT PREVENTS THE ADVERSE EFFECTS OF PSYCHOTROPIC DRUGS | BIOPROJET (FR) | 2005-01-06 | — | — | WO | disclosed |