Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR1E | P28566 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4742791 | 0.98 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3ADRB1HTR1A | |
| SCHEMBL266416 | 0.98 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3ADRB1HTR1A | |
| SCHEMBL5914402 | 0.98 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3ADRB1HTR1A | |
| Hydrochloric Acid SCHEMBL724080 | 0.96 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3ADRB1HTR1A | |
| Bromide SCHEMBL6052803 | 0.96 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3ADRB1HTR1A | |
| SCHEMBL2857779 | 0.82 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3ADRB1HTR1A | |
| SCHEMBL19971988 | 0.82 | CYP2D6 (0.47) | SLC6A2SLC6A4SLC6A3TAAR1HSPA5 | |
| SCHEMBL632694 | 0.82 | GABRA1 (0.55) | SLC6A2SLC6A4SLC6A3TAAR1MAOA | |
| SCHEMBL3071437 | 0.80 | HSPA5 (0.54) | SLC6A2SLC6A4SLC6A3TAAR1HSPA5 | |
| SCHEMBL108067 | 0.80 | GABRA1 (0.64) | TAAR1HSPA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822822-A4 | CONTROLLED RELEASE OF MIOTIC AND MYDRIATIC DRUGS IN THE ANTERIOR CHAMBER | IOLTECH (FR) | 2006-01-11 | — | — | EP | disclosed |
| EP-0822822-A1 | CONTROLLED RELEASE OF MIOTIC AND MYDRIATIC DRUGS IN THE ANTERIOR CHAMBER | IOLTECH (FR) | 1998-02-11 | — | — | EP | disclosed |
| WO-1996032951-A1 | CONTROLLED RELEASE OF MIOTIC AND MYDRIATIC DRUGS IN THE ANTERIOR CHAMBER | GALIN MILES A (US) | 1996-10-24 | — | — | WO | disclosed |