Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.33 |
| ▸ | PPARD | Q03181 | 11/20 | 0.33 |
| ▸ | PPARA | Q07869 | 10/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5989715 | 0.88 | PPARG (0.38) | PPARGPPARDPPARACYP1A2CYP2A6 | |
| SCHEMBL5989709 | 0.88 | PPARG (0.38) | PPARGPPARDPPARACYP1A2CYP2A6 | |
| SCHEMBL5988927 | 0.88 | PPARG (0.38) | PPARGPPARDPPARACYP1A2CYP2A6 | |
| SCHEMBL5991756 | 0.82 | PPARG (0.38) | PPARGPPARDPPARA | |
| SCHEMBL5989015 | 0.82 | PPARG (0.38) | PPARGPPARDPPARA | |
| SCHEMBL5988966 | 0.73 | TRPA1 (0.47) | NPC1ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL5988956 | 0.73 | TRPA1 (0.47) | NPC1ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL5988961 | 0.73 | TRPA1 (0.47) | NPC1ALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL5992147 | 0.73 | PPARG (0.72) | PPARGPPARDPPARA | |
| SCHEMBL18888242 | 0.69 | HDAC1 (0.49) | PPARGPPARDPPARAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |